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If you have gamemaker studio 2 for the mac, do not get the newest update. It has a bug which prevents all projects from being run. Convert to the previous update until this is fixed. That fixed the bug for me.
I installed GMS2 for Mac today for the first time and Studio got stuck when running a short 2min demo with just one sprite/object. After rebooting the MacBook everything worked fine and the project could be run.