The film will be shot entirely in grayscale. Fade in, Mario enters the room, he is smoking a cigarette. The hospital staff glare at him, but say nothing. He picks up a newspaper, flicks to the sports page. It is simply titled "Mario Tennis". He isn't reading, and simply lets his eyes glaze over the text. He removes the cigarette from his mouth, he coughs. Lets out a sigh.
At this moment, Dr Mario walks into the room. He has a grave look on his face and walks towards Mario. His pupils roll upwards from the bland letters on the paper, his ears twitch. Cut to black, cut back to Mario at home. He has noticeably put on weight. His mustache has grown outwards and he is now sporting a beard. Empty beer cans and dorito packets litter the room.
Luigi is trying to contact him, but to no avail. A man that entrenched must solve his own battles, no amount of outside help can aid him anymore. Mario's clothes become visibly stained and face has become bulbous. Luigi, in his worry, has stopped eating. His body visibly lankier, and now he is only filled with resentment.
Mario's clothes now a thick yellow, Luigi's a purple, they both instantly die. The end.